"I-Previcox" yezinja (i-Previcox) iyindlela ephumelelayo yokulwa nokuvuvukala, i-analgesic ne-antipyretic yesimanje esetshenziswa ekwelapheni izinkinga zangemva kokuhlinzwa ezinobunzima obuhlukahlukene, kanye nokwelashwa kokulimala, i-arthritis ne-arthrosis. I-ejenti, eyethulwe i-inhibitor ekhetha kakhulu ye-COX-2, inikela ngemiphumela emihle kakhulu ngesimo sokukhululeka okushesha kakhulu kobuhlungu, ukunciphisa ukukhubazeka nokuthuthukiswa kokuziphatha kwezilwane ezifuywayo ezine-osteoarthritis.
Ukunikeza umuthi
Umuthi kadokotela "Previkox" unqunyelwe izilwane ezifuywayo esiteji sokululama ngemuva kokuhlinzwa, kanye nasekwelapheni okuyinkimbinkimbi kwezifo zemisipha noma zamathambo, lapho kunezinkinga ezihlangene. Njengomthetho, izinkinga ezinjalo zobukhulu obuhlukahlukene zihambisana nalokhu:
- ukuphakamisa kanzima isilwane ngemuva kokuphumula isikhathi eside noma ukulala;
- recumbency njalo;
- izinkinga ngokuhlala nokuma;
- ubunzima bezitebhisi zokuzikhuphula;
- ukwehluleka ukunqoba ngisho nezithiyo ezincane;
- ukukhubazeka okubonakalayo ngenkathi uhamba;
- ukudonsa izidladla nokunyakaza kaningi emilenzeni emithathu.
Isilwane esigulayo asikuvumeli ukuthinta isitho esigulayo, simhlophe ngisho nangokubanjwa okuncane kwejoyinti, sihlushwa ukuvuvukala kwemisipha nomkhuhlane. Lapho kukhona lezi zimpawu, odokotela bezilwane bakhetha ukunikezela umuthi "i-Previcox" ezinjeni, ezakhiwa yinkampani i- "Merial" (France).
Ukwakheka, ifomu lokukhishwa
I-Previcox iqukethe isithako esiyinhloko esisebenzayo - i-firocoxib, kanye ne-lactose, enikeza umkhiqizo ukunambitheka okumnandi. I-binder iyi-cellulose elashwa ngokukhethekile. Ngaphezu kwalokho, amaphilisi e-Previcox afaka phakathi i-silicon dioxide, esebenza njengesisekelo, kanye nama-carbohydrate alula, ukwakheka okunephunga "kwenyama ebhemayo" nodayi ophephile ezilwaneni ngendlela eyinsimbi. Ingxenye yokugcina inomphumela omuhle ohlelweni lwe-hematopoietic lwesilwane.
Namuhla umuthi "i-Previkox" ukhiqizwa yimithi yokwelashwa kuphela ngesimo samaphilisi anombala onsundu. Amaphilisi agcwele amabhamuza epulasitiki noma e-foil, izingcezu eziyishumi lilinye. La mabhamuza asemabhokisini amakhadibhodi ajwayelekile. Phakathi kwezinye izinto, amaphilisi e- "Previkoks" ahlanganiswe ngamabhodlela akhethekile, alula kakhulu e-polyethylene. Akunandaba nobunjalo befomu lokukhishwa, iphakethe ngalinye lomuthi wezilwane lihambisana nemiyalo enembile nenemininingwane yokusetshenziswa.
Ngasohlangothini ngalunye lwethebhulethi yasekuqaleni kunolayini okhethekile wokuhlukanisa nohlamvu "M", ngaphansi kwalo kunenombolo ethi "57" noma "227", ekhombisa ivolumu yesithako esikhulu esisebenzayo.
Imiyalo yokusetshenziswa
Umthamo wezilwane ezilwa nokuvuvukala kanye nomuthi we-analgesic ngqo uncike ngosayizi wesilwane:
- isisindo esingu-3.0-5.5 kg - ½ ithebhulethi 57 mg;
- isisindo 5.6-10 kg - 1 ithebhulethi 57 mg;
- isisindo 10-15 kg - 1.5 amaphilisi 57 mg;
- isisindo 15-22 kg - ½ ithebhulethi 227 mg;
- isisindo 22-45 kg - 1 ithebhulethi 227 mg;
- isisindo 45-68 kg - 1.5 amaphilisi 227 mg;
- isisindo 68-90 kg - 2 amaphilisi 227 mg.
Kuyadingeka ukuthatha isidakamizwa kanye ngosuku. Isikhathi esiphelele sokwelashwa sinqunywa udokotela wezilwane futhi, njengomthetho, siyahluka kusuka ezinsukwini ezingama-2-3 kuye kwesonto elilodwa. Ezimweni zokusetshenziswa isikhathi eside komuthi, isilwane sinikezwa amandla okulawula odokotela bezilwane. Lapho kunqunywa ukuhlinzwa, umthamo owodwa we-Previkox unikezwa ngokushesha ngaphambi kokuhlinzwa, futhi ngokushesha ngemuva kwawo, izinsuku ezintathu.
Kuyadingeka ukuthi usebenzise isidakamizwa i-Previcox ngemuva kwamahora angama-24, kepha uma ukuphuza isidakamizwa kuphuthelwa nganoma yisiphi isizathu, kufanele kuqale kabusha ngokushesha okukhulu, ngemuva kwalokho ukwelashwa kufanele kuqhutshekwe ngokuya ngemithi yokwelashwa enconyiwe.
Izinyathelo zokuzivikela
Ngaphandle kokungabikho kwezakhi ezinobuthi ekwakhiweni kwe-Previcox, ngaphambi kokusebenzisa lesi sidakamizwa, kufanele ufunde ngokucophelela imiyalo yokusetshenziswa futhi ulandele ngokuqinile zonke izincomo ezinikezwe ngudokotela wezilwane. Phakathi kwezinye izinto, ngokusho komkhuba wamanje wezilwane, i-Previkox inqatshelwe ngokuphelele ukusetshenziswa kanyekanye nama-antibiotic, kanye ne-corticosteroids noma amanye ama-non-steroidal agents.
Impilo yeshalofu ineminyaka emithathu kusukela ngosuku lokwenziwa komuthi oboniswe ephakeji, ngemuva kwalokho umuthi kufanele ulahlwe ngemfucuza yasendlini futhi akumele usetshenziswe.
Izimo
Ngokuya ngemiyalo yokusetshenziswa enamathiselwe kumuthi wezilwane i-Previkox, lo muthi awunconywa ukuthi usetshenziswe yizinja ezikhulelwe kanye nezinsana ezincelisayo, kanye nemidlwane engaphansi kwamasonto ayishumi ubudala. Leli thuluzi liphikisana nezilwane ezifuywayo ezincane kakhulu, ezinesisindo esingaphansi kwamakhilogremu amathathu.
Futhi, isidakamizwa "i-Previkox" siyaphikiswa ukuze sisetshenziswe ezifweni eziningi ngendlela ebukhali noma engalapheki, lapho kukhona ukungabekezelelani ngakunye entweni eyodwa noma eziningana ezisebenzayo ngasikhathi sinye. Kuyinto engathandeki kakhulu ukunquma umuthi wokuqeda ukuvuvukala wesimanje okhetha kakhulu lapho kukhona umlando wenja wokuthambekela kokungazwani komzimba nobukhulu obuhlukahlukene.
Umuthi wokubulala izinzwa awunqunyelwe i-hemorrhagic syndrome, kanye nokungajwayelekile okukhulu ekusebenzeni kwezinhlelo zenhliziyo nemithambo yegazi, lapho kukhona ukwehluleka kwezinso nokugula kwesibindi okuhlukahlukene, kufaka phakathi ukwehluleka kwesibindi. Kuyinto engathandeki ngokuphelele ukusebenzisa leli khambi lezilwane uma kwenzeka kukhona okungahambi kahle emsebenzini wesisu kanye nomgudu wamathumbu, ikakhulukazi uma kwenzeka isifo sesilonda se-peptic noma uma isilwane sinobungozi bokuphuma ngaphakathi.
I- "Previcox" iyisidakamizwa esisha uma kuqhathaniswa, ngakho-ke namuhla ama-analogue alo muthi awavamile. Izidakamizwa ezifakazelwe kahle i- "Norocarp" ne- "Rimadil" zingabalwa ngenombolo yazo.
Okuqhamuka uma udla imishanguzo
Isithako esisebenzayo se-firocoxib sisebenza ngqo emaphuzwini okuvuvukala ngokwaso futhi cishe asinawo umthelela omubi ekusebenzeni kohlelo lokugaya ukudla noma ebuqothweni bezindonga zesisu. Kodwa-ke, ezinye izilwane ezifuywayo zingathola isifo sohudo, ukuhlanza noma ukucasuka esiswini lapho kuthatha i-Previcox. Izimpawu ezinjalo ezilwaneni, njengomthetho, zivele zinyamalale kungakapheli usuku olulodwa.
Uma izimpawu ezingenhla zokungabekezelelani komzimba wesilwane esinemilenze emine sezingxenye ezisebenzayo ziqhubeka izinsuku ezimbalwa, kuyilapho ukwehla kwesisindo somzimba wesilwane kuqhathaniswa nokuvela kokuvela kokucaca kokungezwani komzimba noma iminonjana yegazi endleni, kuyadingeka ukuyeka ukusebenzisa umuthi, ngemuva kwalokho kubalulekile ukufuna izeluleko kudokotela wezilwane.
Ngenkathi umuthi "i-Previkox" ukhanselwa futhi wasetshenziswa okokuqala, akukho miphumela ethize emzimbeni wesilwane eveziwe, kepha ukusetshenziswa komuthi izinyanga ezintathu noma ngaphezulu kuzodinga ukuqashwa kwesimo senja ngudokotela wezilwane ohambele.
Izindleko ze-Previcox
I-COX-2 inhibitor ekhethiwe yaziwa ngaphansi kwegama lomhlaba wonke elingelona elokuphathelene ne-firocoxib. Ifomu lokulinganisa elinjalo ngesimo samathebulethi okuphathwa ngomlomo kufanele lithengwe ngokuqinile emakhemisi wezilwane noma amanye amaphuzu wokuthengisa akhethekile. Ngaphezu kwalokho, kufanele uqiniseke ukuthi hhayi kuphela usuku lokukhishwa olukhona ebhokisini noma ebhodleleni, kodwa futhi nedatha yenombolo yeqoqo lokukhiqiza.
Intengo emaphakathi yomuthi "Previcox" okwamanje:
- amaphilisi 57 mg kwibhamuza (BET), izingcezu ezingama-30 - ama-ruble angama-2300;
- Amaphilisi angama-227 mg ku-blister (BET), izingcezu ezingama-30 - ama-ruble angama-3800.
Ngaphambi kokuthenga umuthi wokulwa nokuvuvukala okhetha kakhulu i-non-steroidal, kufanele uqiniseke ukuthi usuku lokuphelelwa yisikhathi lomuthi aluphelelwe yisikhathi, futhi njengoba kukhonjiswa umenzi kwiphakeji: Boehringer Ingelheim Promeco S.A. de C.V., eFrance.
Izibuyekezo mayelana Previkox
Inzuzo enkulu engenakuphikwa yomuthi wezilwane i- "Previcox" ukwehluka kwemithamo, okuvumela ukuthi kunikezwe umuthi ezifuyweni ezinobukhulu obuhlukahlukene. Ngasikhathi sinye, abanye abalimi abanolwazi bayaqaphela ukuthi kungenzeka ukuthi esikhundleni salomuthi kufakwe iRimadil, kepha ongoti abaningi abenza umuthi wezilwane zasekhaya belapha lesi sidakamizwa esingeyona i-steroidal ngezinga elithile lokuqapha, elibangelwa ingozi enkulu kakhulu yemiphumela emibi. Ngokusho kodokotela bezilwane, maqondana nalokhu, amalungiselelo "i-Previkox" ne "Norocarp" aphephe kakhulu empilweni yesilwane.
Umuthi wezilwane i- "Previcox" ungowesigaba sezinto ezinobungozi ngokuya ngezinkomba zokuchayeka, ngakho-ke, kumithamo enconyiwe, umuthi wezilwane awukwazi ukuba ne-embryotoxic, teratogenic kanye ne sensitizing effect. I-ejenti engeyona i-steroidal izibonakalise kahle ekusizeni i-pain syndrome yobukhali obuhlukahlukene ngemuva kwezinqubo eziyinkimbinkimbi zamazinyo nokungenelela kokuhlinzwa kwamathambo, kanye nokusebenza kwezicubu ezithambile. Kumele kukhunjulwe ukuthi isigamu sethebhulethi esingasetshenzisiwe singagcinwa ku-blister izinsuku ezingekho ngaphezu kweziyisikhombisa.
Ngaphambi kokwenza isinqumo esivuna umuthi wezilwane "i-Previkox", umuntu kufanele abheke ukuthi umuthi onjalo okhetha kakhulu ongasebenzisi i-steroidal onesenzo sokulwa nokuvuvukala awuhloselwe ukusetshenziswa yizilwane ezikhiqizayo. Phakathi kwezinye izinto, lesi sidakamizwa asibekiwe kanyekanye nanoma iziphi ezinye izidakamizwa ezingezona ukuvuvukala kanye ne-glucocorticosteroids. Uma izimpawu zokudlula ngokweqile zivela ngesimo se-salivation esiningi, ukuphazamiseka kwendlela yamathumbu, kanye nokudangala okusobala kwesimo esijwayelekile sesilwane, kuyadingeka ukuthi unikeze inja usizo lokuqala ngokushesha futhi uyihambise emtholampilo wezilwane.
