Umuthi "Roncoleukin" ungowesigaba sama-ejenti e-immunomodulatory athandwa kakhulu futhi akhokhelekayo ahlawulela kahle ukusweleka okukhulu kwe-interleukin-2 engapheli, eyenza sikwazi ukukhiqiza umphumela wayo obangelwa izingxenye eziyinhloko. Lesi sidakamizwa, esivame ukunikezwa odokotela bezilwane, siyi-analogue ehlelekile futhi esebenzayo ye-interleukin-2 evamile yomuntu.
Ukunikeza umuthi
Ama-T cell abizwa ngokuthi umsizi, amelwe ama-lymphocyte akhethekile, anomsebenzi wokukhiqiza i-interleukin emzimbeni.... Into yenziwa njengempendulo yomzimba kumagciwane angenayo. I-IL ekhiqizwayo ivuselela ukukhiqizwa kwe-T-killers, futhi ngasikhathi sinye yandisa ukuhlanganiswa kwezinto ngaphakathi kwabasizi be-T. Izici zesimiso sokusebenza kwe-IL zihambisana nokukwazi kwayo ukubopha kalula kuma-receptors athile amaselula ama-antigen ahlukahlukene angena emzimbeni wabantu hhayi kuphela, kodwa nasezilwaneni.
Umuthi "Roncoleukin" uyasebenza ezimweni eziningi:
- izimo ze-septic ezihambisana nokuzikhusela komzimba;
- ushintsho lwe-septic lohlobo lwangemva kokuhlukumezeka;
- ukutheleleka kwesilonda ngemuva kokuhlukumezeka okukhulu;
- i-dermatitis, i-dermatoses, i-eczema, izilonda ze-trophic;
- izinkinga zokuhlinzwa nezokubelethisa;
- ukushisa okushisayo nokwamakhemikhali;
- i-osteomyelitis;
- i-pneumonia enamandla, i-pleurisy ne-bronchitis;
- kaningi izifo zokuphefumula eziphindaphindayo;
- isifo sesisu kanye ne-peritonitis;
- i-pancreatic necrosis ne-pancreatitis enamandla;
- isifo sofuba esithuthuka ngokushesha;
- izinguquko zomdlavuza ezicutshini zezinso;
- amagciwane, amagciwane, ukhunta kanye nemvubelo izilonda.
Ngakho-ke, i-interleukin inomphumela omuhle kakhulu ekukhiqizeni amaseli wokuvikela emzimbeni wesilwane, omelwe ngama-monocyte, ama-macrophage, ama-B ne-T lymphocyte. Into esebenzayo ithuthukisa ukusebenza kahle kwamaseli weLangerhans, angama-macrophage we-intraepidermal.
Kuyathakazelisa! Izici zemithi yomuthi "Roncoleukin" zibangela ukubhujiswa okusheshayo cishe kwanoma iyiphi i-microflora engena emzimbeni wesilwane, futhi kunikeza nokuvikelwa okuthembekile kuma-bacterium, amagciwane, imvubelo kanye nama-fungal agents.
Izinkomba zomsebenzi wababulali be-T zixhomeke ngqo kwi-interleukin-2 ephindaphindayo (i-rIL-2), i-analogue ehlelekile futhi esebenzayo ye-interoukous-2 engapheli. Phakathi kwezinye izinto, lokhu ketshezi kakhulu kwandisa ukumelana komzimba kwamanye amangqamuzana isimila, kusheshisa izinqubo ukuthola kwabo futhi ukubhujiswa okwalandela.
Ukwakheka, ifomu lokukhishwa
I-Immunomodulator "Roncoleukin" iyindlela elula yokulinganisa engasetshenziswa ngendlela ye:
- i-lyophilized powder yesisombululo - 1 ampoule;
- i-interleukin-2 ephindaphindekayo yabantu engu-0,25 mg, i-0.5 mg ne-1 mg noma i-250 eyizinkulungwane, i-500 eyizinkulungwane noma i-1 million IU, ngokulandelana.
Abamukeli besidakamizwa sokuqeda amandla:
- i-sodium dodecyl sulfate solubilizer - 10 mg;
- i-stabilizer D-mannitol - 50 mg;
- ukunciphisa i-ejenti dithiothreitol - 0.08 mg.
Ibhokisi lamakhadibhodi liqukethe ama-ampoules amahlanu, kanye nommese olula we-ampoule. Isisindo esinamandla kanye ne-lyophilized powder, ehlanganiswe nethebhulethi emhlophe noma ephuzi, i-hygroscopic, incibilika kalula uma usebenzisa isisombululo se-isotonic sodium chloride.
Imiyalo yokusetshenziswa
Namuhla, kunezindlela ezahlukahlukene zokusebenzisa isidakamizwa sanamuhla sokuzivikela komzimba, kepha isilinganiso nobude benkambo yokwelashwa kufanele kukhethwe ngudokotela wezilwane. Umuthi ulawulwa ngaphansi kwesikhumba noma ngemithambo, ngezikhathi zamahora angama-24 noma angama-48.
Inkambo yokwelashwa ejwayelekile imijovo emibili noma emithathu. Ukubalwa okujwayelekile kungu-10,000 IU / kg. Ukwelashwa kwezifo ze-oncological kufaka ukusetshenziswa kwemijovo emihlanu, futhi inkambo iyaphindwa cishe inyanga. I-Immunomodulatory "Roncoleukin" ibuye ibekwe ngesikhathi nangemva kwemisebe kanye nangemithi yokwelashwa ngamakhemikhali.
Izindlela ezijwayelekile, ezamukelwa ngokujwayelekile zokusebenzisa umuthi "Roncoleukin" ezilwaneni ezifuywayo ezine-ezine:
- ukusetshenziswa kwe-immunomodulator njenge-adjuvant yokugoma nokuqeda ukucindezeleka phakathi kokukhohlisa okuhlukahlukene kungumthamo owodwa we-5000 IU / kg;
- Ukwelashwa kwezifo zesikhumba kwenziwa ngokubeka imijovo emithathu kuya kwemihlanu ngesilinganiso se-10,000 IU / kg;
- Ukuvinjelwa kwezifo ezibangelwa amagciwane, amagciwane kanye nefungal kuhilela ukuphathwa kwesikhumba ngesilinganiso se-5000 IU / kg ngesimo somjovo owodwa noma emibili enesikhawu sezinsuku ezimbili;
- ngezifo zohlelo lokuchama kunconywa ukuthi ulusebenzise ekwelashweni okuyinkimbinkimbi ngendlela yemijovo emibili noma emithathu ye-10,000 IU / kg ngezikhathi ezithile zansuku zonke;
- yesifo se-renal polycystic, lesi sidakamizwa sisetshenziswa ekwelashweni okuyinkimbinkimbi ngendlela yemijovo emihlanu ka-20,000 IU / kg esikhaleni sezinsuku ezimbili.
Izinyathelo zokuvimbela zenziwa kabili ngonyaka ngezikhathi ezinyangeni eziyisithupha... Nge-cystitis kanye ne-urolithiasis, isidakamizwa sokuzivikela emzimbeni kufanele sinikezwe ngaphakathi noma nge-intercystially. Inkambo yokwelashwa iphindaphindwa inyanga eyodwa ngemuva komjovo wokugcina. Futhi, umuthi "Roncoleukin" usetshenziselwa ukulungiselela izilwane ezifuywayo zemibukiso. Kulokhu, kunconywa ukusebenzisa umthamo we-5000 IU / kg, ophathwa kabili ngekhefu lansuku zonke, kepha umjovo wokugcina kufanele usetshenziswe okungenani ezinsukwini ezimbili ngaphambi kombukiso.
Kuyathakazelisa! Esimweni ngasinye sokuqokwa kwe-immunomodulator, indlela yokufaka kumele ilandelwe, futhi ukwephula lo mthetho kungadala ukwehla okukhulu ekusebenzeni komuthi.
I-immunomodulator "Roncoleukin" inconywe kahle njengendlela entsha yokwelashwa kwesondlo kwezilwane ezifuywayo ezibuthakathaka noma ezindala. Ngale njongo, odokotela bemitholampilo yezilwane banquma umuthi njalo ngekota, ngesimo somjovo owodwa noma emibili ka-5000-10000 IU / kg. Ukukhuthazeka kokuzivikela kwangaphakathi kwamantshontsho ane-reflex ebuthakathaka ebuthakathaka kufaka ukuphathwa okuphindwe kabili ngomlomo noma okungaphansi kwesilinganiso sika-5000 IU / kg ngesikhawu sansuku zonke.
Izimo
Noma ngabe umuthi wokwelapha nowokuvikela "Roncoleukin" uvame ukubekezelelwa kahle yizilwane ezifuywayo, kwesinye isikhathi ukusabela okungekuhle kuyaphawuleka ngokusetshenziswa kwawo. Ukuphikisana okuyinhloko kwendawo lapho ukusetshenziswa kwesidakamizwa sokuvikela kunganconywa kufaka phakathi:
- uma isilwane sinokungezwani komzimba nemvubelo, okuyingxenye yomuthi;
- izifo ezizimele;
- ukwehluleka kwenhliziyo yamaphaphu ebangeni lesithathu;
- Ukwehluleka kwenhliziyo
- izilonda zobuchopho zamazinga ahlukahlukene obunzima;
- ukuphela kwesigaba se-renal cell carcinoma;
- isikhathi sokukhulelwa.
Kwezinye izilwane, i-hypersensitivity ebucayi ibonakala kumuthi. Phakathi kwezinye izinto, ngokuqapha okukhulu, umuthi unikezwa amakati anezinkinga ezihambisana nesimo sezinso noma isibindi.
Izinyathelo zokuzivikela
Ngesikhathi sokulungiselela, inani elijwayelekile lokuchithwa komuthi alidluli imizuzu emithathu... Isixazululo esilungisiwe se-immunomodulatory kufanele singabi nombala, sibonakale, singabinakho ukungcola.
Umuthi "Roncoleukin" uhambelana ngokuphelele namanye amalungiselelo amaningi okwenziwa kwemithi. Noma kunjalo, lapho usebenzisa i-immunomodulator, le mithetho elula elula kufanele ilandelwe:
- akunakwenzeka ngokuphelele ukujova i- "Roncoleukin" kanye nezixazululo eziqukethe i-glucose, ngoba kulokhu izinkomba zomsebenzi zomuthi zincishisiwe ngokuphawulekayo;
- akuvunyelwe ukubeka ngasikhathi sinye i- "Roncoleukin" ngemithi ye-corticosteroid yokusetshenziswa okuhlelekile noma kwasendaweni.
Enqubeni yokusebenzisa umuthi wokwelashwa obekiwe, kunconywa ngokuqinile ukuthi kugcinwe ngokuqinile imithamo ekhonjiswe ngudokotela wezilwane. Ngaphandle kwalokho, ngemuva kokwelashwa okwenziwayo, izinga lokushisa lomzimba wesilwane lingakhuphuka noma ukwehluleka kwesigqi senhliziyo kubonwe.
Okubalulekile! Gcina ngokucophelela ukulandelana, kanye nemithi yokwelashwa ebekwe ngudokotela wezilwane, ngaphandle kokweqa imijovo, ngoba uma kungenjalo ukusebenza komthelela wezidakamizwa kuncipha kakhulu.
Ngenani eliningi ngokweqile lesisombululo se-immunomodulatory esengene egazini, izimpawu zokudlula ngokweqile kufanele zimiswe ngemithi elwa nokuvuvukala kanye nama-analeptics akhethekile.
Okuqhamuka uma udla imishanguzo
Ezimweni lapho umuthi usetshenziswa ngemithamo eyanele, futhi uphinde unikezwe isilwane sisebenzisa imizila enconyiwe, imiphumela emibi ngokuvamile ayibonwa. Umjovo ongaphansi kwesidakamizwa "Roncoleukin" kwesinye isikhathi ungahambisana nokuzwela okubuhlungu kwesikhashana ngesimo "sokusha".
Ngokuphulwa okuphawulekayo kwemithetho yokusetshenziswa kwe-immunomodulator, ngokushesha nje ngemuva kokwethulwa, kukhona ukwanda kwezinga lokushisa lomzimba lendawo kanye nokujwayelekile, kanye nokwanda okungaziwa kakhulu kokushaya kwenhliziyo. Ukweqiwa okuphawulekayo komthamo lapho ufakwa ngemithambo yegazi kungadala ukuthi isilwane sihlakulele ukusongela noma ukufa kwe-anaphylactic okusongela impilo. Isidakamizwa esingahlanjululiwe esifakwe ngaphansi kwesikhumba sicasula izinqubo zokuvuvukala zasendaweni.
Izindleko zeRoncoleukin zamakati
Izindleko ze-interleukin-2 ephindaphindekayo, i-analogue ehlelekile nesebenzayo ye-endoukous interleukin-2, eqhelelene namaseli emvubelo yombhaki engeyona eye-pathogenic Saccharomyces servisiae enofuzo lomuntu olufakiwe, iyabiza impela. Intengo emaphakathi yalesi sidakamizwa iyahluka ngokuya ngokuhlushwa kwento esebenzayo futhi namuhla:
- Ama-ruble angama-50 ayizinkulungwane ezingama-50 - 190-210;
- Izinkulungwane eziyi-100 ze-IU - ama-ruble angu-240-260;
- 250 izinkulungwane IU - 340-360 ruble;
- Izinkulungwane ezingama-500 IU - 610-63- ruble.
Kunconywa ukuthi uthenge i-immunomodulator yesizukulwane esisha esebenzayo kuphela emakhemisi wezilwane. Lapho uthenga, qiniseka ukuthi uhlola ikhwalithi yomuthi, kanye nesikhathi sokuphelelwa yisikhathi.
Ukubuyekezwa kukaRoncoleukin
I-ejenti yokuzivikela "i-Roncoleukin" inqunyelwe odokotela bezilwane hhayi kuphela ezifuywayo ezindala, kepha futhi nezilwane ezisanda kuzalwa, izilwane ezindala nezibuthakathaka. Umphumela oyinhloko walesi sidakamizwa usekelwe ekuvuseleleni amasosha omzimba, futhi ngenxa yokwanda kokuzivikela, umzimba wesilwane uthola ukumelana namagciwane ahlukahlukene, amabhaktheriya, isikhunta namanye amagciwane we-pathogenic.
Njengoba ukubuyekezwa kwabanikazi bekati kubonisa, amacala lapho i-immunomodulator ifakazele ukusebenza kwawo okuphezulu ahluke kakhulu.... Ithuluzi lizibonakalise kahle ekwelapheni i-panleukopenia, i-parvovirus enteritis nezinye izifo ezithathelwanayo, futhi libuye lazibonakalisa kahle ekwelapheni izifo zokuphefumula. Ngenxa yesicelo, izinqubo zokuvuselela ziyavuselelwa futhi ukuphulukiswa kwamanxeba angapholi kakhulu kunalokhu kuyinkimbinkimbi futhi isikhathi eside.
Ngokusho kokubona okuningi, lesi sidakamizwa sisiza ukukhulula ngokushesha isilwane esivela ku-stomatitis, i-gingivitis nezinye izifo zomlomo womlomo, ikulungele kahle ukwelashwa kwezifo zesikhumba (i-eczema ne-dermatitis), kanye ne-conjunctivitis. Ngokuhlanganiswa namanye amalungiselelo okwenziwa kwemithi noma amakhambi esintu, i-immunomodulator "Roncoleukin" imelana kahle nokusha kanye nesithwathwa, amanxeba aqaqekile, kanye nokuqhekeka kanye nemihuzuko emibi.
Kuyathakazelisa! Muva nje, umuthi ubulokhu unqunywe ngesikhathi sokugoma futhi usiza ukwakha ukuzivikela okuqinile ezifweni ezivame kakhulu zegciwane.
Isidakamizwa "iRoncoleukin", ngokusho kochwepheshe bezilwane, siqinisekisiwe ukucindezela umsebenzi wezinto eziningi eziyingozi futhi sisheshise kakhulu inqubo yokuthola kabusha isilwane esinemilenze emine. Kungenxa yalesi sizathu ukuthi i-immunomodulator evame ukubekwa ngokuhambisana nezidakamizwa, isenzo sazo okuhloswe ngaso ukuqeda ngempumelelo izimbangela zezinguquko ze-pathological noma izimpawu zazo ezijwayelekile.
Kuzothakazelisa futhi:
- I-Maxidine yamakati
- I-Milbemax yamakati
- IPirantel yamakati
- IGamavite yamakati
Kwezokwelapha izilwane, ama-analogue omuthi "Roncoleukin" angasetshenziswa kahle, afaka phakathi i- "Proleukin" ne "Betaleukin". Kodwa-ke, naphezu kokusebenza kwabo okuphezulu futhi okungenakuphikwa, yi-immunomodulator "Roncoleukin" engeyesizukulwane esisha semithi, ngakho-ke odokotela bezilwane abeluleki ukuthi bonge impilo yezilwane futhi banikeze lo muthi wanamuhla.
